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Created Feb 2025; uploading is ongoing …
Author: LISI Daniele Roma Italy
A complex interaction of autoantibodies against the parietal cell progressively destroy them, inducing hypochlorhydria, while autoantibodies against the intrinsic factor impair the absorption of vitamin B₁₂. The resulting cobalamin deficiency manifests with megaloblastic anaemia and neurological and systemic signs and symptoms collectively known as pernicious anaemia.